When successful, stem cell therapies can provide the transplanted host with significant benefits; however, there is always risk involved.
The neurological complications associated with stem cell therapy are very frequent and are associated with high morbidity and elevated mortality. The frequency of clinically significant neurological complications in these patients can vary between 10% and 40%. Patients who have received an unrelated allogeneic transplant have a higher risk of complications than those treated with autologous transplantation. This fact highlights the importance of immunological factors in the pathogenesis of these types of complications. Find out how Stem Cells can cure baldness without sideeffects.
Some risk factors for the development of neurological complications in stem cell transplantation therapy include acute myeloid leukemia as the underlying disease, the use of total body radiotherapy in the conditioning period, the use of intrathecal methotrexate in the pre-transplant phase, immunosuppression prolonged and the development of graft-versus-host disease or GVHD.